The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL. For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection.For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection.Preparation of Solutions for Intramuscular / Intravenous Injections: Usual duration is 4 to 14 days in complicated infections, longer therapy may be required. Meningitis: 100 mg/kg IV or IM in single daily dose or (or in equally divided doses twice a day) Maximum dose: 4 gm/dayĭuration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared.Acute bacterial otitis media: 50 mg/kg IM in single dose Maximum dose: 1 gm/day.Pneumonia, Bronchitis, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day) Maximum dose: 2 gm/day.Infants and Children (01 month or older): The usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day). Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery.Uncomplicated gonococcal infections: 250 mg IM as a single dose.Pneumonia, Bronchitis, Acute bacterial otitis media, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections, Meningitis: 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) Maximum dose: 4 gm/day.The drug is highly protein bound (95%).Īdult: The usual dose is 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day). About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. Ceftriaxone is not metabolized in the body. A remarkable feature of Ceftriaxone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone has a high degree of stability in the presence of beta lactamases. Like other cephalosporins and penicillins, Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Perioperative prophylaxis of infections associated with surgeryĬeftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic.A list of bone analyses that we offer in our animal models can be found in our list of bone analysis services.Ceftriaxone is indicated for the treatment of the following major infections: We also provide tailored study setups for testing biosimilars and functional foods that have less extensive regulatory requirements. Pharmatest has specific standard study setups for testing compounds with anti-catabolic and anabolic bone effects. Preclinical efficacy studies can also be performed with intact male rats, or intact male mice that require lower amount of test compound. Efficacy of the best compound can then be confirmed with more extensive and longer studies. When necessary a preliminary 2-week study can be first performed for identifying the best out of several potential compounds and finding its optimal doses. Pharmatest can help you in determining the efficacy of your new drug candidates for male osteoporosis with the rat ORX model. The rat orchidectomy (ORX) model is the most commonly used animal model of androgen deficiency and male osteoporosis. The development of male osteoporosis is associated with several risk factors, including androgen deficiency. Osteoporosis affects aging men and leads to an increased risk of bone fracture.
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